He graduated from the Faculty of Architecture in Zagreb in 1980, where he worked until 1984 as the associate assistant. He has been working as a free-lance architect and the head of his own atelier Rusan arhitektura since 1986.
He participated at iba (Internationale Bauaustellung) in Berlin in 1987 as the author of the exhibition Zagreb, ah Zagreb. He is the author of the exhibition Oris Outline of Ideas. He is one of the authors of the exhibition Continuity of Modernity – Fragments of Croatian Architecture from Modernism to 2010. Together with Vedran Mimica and Maroje Mrduljaš he is the author of the book Contemporary Croatian Architecture – Testing Reality.
During the 80s and the 90s he was the member of editorial boards of magazines published by Croatian Association of Architects: Čovjek i prostor (Man and space) and Arhitektura (Architecture).
Since 1998 he has been the publisher and editor of the magazine Oris. For scientific-research, critical and theoretical as well as for journalistic work in the field of architecture Oris was twice the recipient of the Neven Šegvić Award of the Croatian Association of Architects.
Andrija Rusan was the recipient of the Drago Galić Award of the Croatian Association of Architects for the best residential architecture in 1997, of the Dedalo Minose Prize for the Lumenart office building in Pula in 2007. In 2006 he was appointed the Croatian commissioner for the 10th International Architecture Exhibition, Biennale of Venice.
Parallel to his activities as publisher and creator of exhibitions he has also designed and realized a number of interiors, family houses and commercial buildings.
His work appears in the Phaidon Atlas of 21st World Architecture, Atlas Global Architecture circa 2000 (Fundación bbva) and in the book Nano Materialien (Birkhäuser) by Sylvia Leydecker.
His architectural works are published in numerous books and magazines in Croatia and abroad. Also, he has held number of lectures about his work and the activities of oris – House of Architecture association.